Endocrine Abstracts

Calcification is a physiological process in bone but occurs also pathologically in the vasculature, favouring cardio- and cerebrovascular diseases (CVD). Vitamin K metabolites, particularly K1 and MK-4, are associated with decreased vascular calcification especially in patients with chronic kidney disease. We investigated the expression of components of the vitamin K cycle (VKC) and the MK-4 synthesis (MKS) in aorta and bone of 26 brain dead organ donors in order to identify d...

Background: Calcification occurs physiologically in bone and pathophysiologically in the vasculature. Cardiovascular diseases are among the most common causes of death within patients with chronic kidney disease and crucial for kidney transplantation (RTX) outcomes.Methods and aim: We investigated the pattern and the onset of expression of regulators of calcification (RC) in the arteria iliaca externa in 26 donors (D) and 25 recipients (R) of RTX to iden...